Fixed drug eruption (FDE) appearing few hours after ingestion of a tetracycline. FDE lesions usually develop 30 minutes to 8 hours after drug intake. On continuing the course the involved site flared with each exposure. He first ingested a tetracycline a year ago without having a drug eruption. What is this period called? Positive patch test reactions are observed at the site of previous lesions harbouring significant numbers of intraepidermal CD8+ T cells with an effector–memory phenotype. What is the refractory period in this regard? What is non-pigmenting FDE? What is wandering FDE?
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