Thursday, 10 November 2016

Management of pearly penile papules




Reassurance is usually sufficient but cryotherapy and laser treatment can be effective if required.




This page was last updated in November 2016

Nonsense read‐through drugs in the treatment of epidermolysis bullosa






Nonsense mutations create truncated mRNA molecules that subsequently are degraded before they are translated into non-functional protein products.  Nonsense  readthrough  drugs  allow  the  production  of  a  viable  protein  product via the translation machinery. Several nonsense read-through drugs are currently under investigation for the treatment of epidermolysis bullosa.




This page was last updated in November 2016






Saturday, 1 October 2016

Pityriasis alba sparing the face



Pityriasis (Gk pityron, bran) alba (L albus, white) is a pattern of dermatitis in which hypopigmentation (with branny scaling) is the most conspicuous feature.  Erythema (with branny scaling) usually precedes the development of hypopigmentation but this is often relatively mild. At times, there may be initial minimal serous crusting.  The hypopigmentation is more noticeable in pigmented skin, summer and after sun tanning. The scaling is more noticeable in winter. 

The individual lesion is a rounded, oval or irregular hypopigmented patch that is usually not well marginated.  The course is extremely variable.  Post inflammatory hypopigmentation (without scaling) ensues before resolution occurs. Recurrent crops of new lesions may develop at intervals.  Pityriasis alba is sometimes a manifestation of atopic dermatitis but it is certainly not confined to atopic individuals.

Although pigment is reduced, melanocyte numbers are not (the activity is decreased) and may even be increased relative to healthy skin.

Pityriasis alba occurs predominantly in children between the ages of 3 and 16 years. Both sexes are equally susceptible. The lesions are often confined to the face, and are most common around the mouth, chin and cheeks.  In 20% of affected children the neck, arms and shoulders are involved as well as the face.  Less commonly, the face is spared and there are scattered lesions on the trunk and limbs as shown on this patient’s skin.

The age incidence, the fine scaling and the distribution of the lesions usually suggest the diagnosis. Mycosis fungoides may present with lesions clinically resembling pityriasis alba. This condition may also be difficult to distinguish histopathologically, so follow-up and repeat biopsies are sometimes required.



Topical calcineurin inhibitors, pimecrolimus and tacrolimus, have been reported to speed recovery of skin colour.







Topical pimecrolimus has been reported to speed recovery of skin colour as shown here.
This page was last updated in October 2016. 



Saturday, 10 September 2016

Pubertal growth striae misdiagnosed as a sign of physical abuse




A 14-year-old boy presented with multiple horizontal striae of varying length on the mid-back. His parents sought explanation for these lesions when the boy was seen by another physician who assumed that the lesions were a sign of physical abuse.  On seeing the patient with his father, the diagnosis of pubertal growth striae was made.  The history was unremarkable and no signs of Marfan syndrome or Cushing syndrome were detected. Linear focal elastosis, where the lesions are yellow and raised, was excluded.  Only reassurance was necessary.

Transverse striae of the back are common among healthy young men.* They are characterised histologically by thinning of the overlying epidermis, with fine dermal collagen bundles arranged in straight lines parallel to the surface in the direction of the presumed stressThese adolescent growth striae may be mistaken for signs of physical abuse hence the importance of their recognition. There is no proven treatment but they become inconspicuous over time.


*Carr RD, Hamilton JF. Transverse striae of the back. Arch Dermatol 1969; 99: 26-30.






This page was last updated in August 2016

Friday, 12 August 2016

Dermographism



Dermographism (writing on the skin) is an exaggerated wealing tendency when the skin is stroked.  It is the most common form of inducible urticaria, followed  by  cholinergic  urticaria. More than one form of inducible urticaria may occur in the same patient.

The  triple response*  of  capillary  vasodilatation (initial red line),  surrounding  flare  due  to  axon reflex‐induced  dilatation  of  arterioles  and weal (increased permeability of the capillaries and postcapillary venules, with consequent extravasation of fluid and oedema), after  stroking  the  skin was first  described  by  Lewis  and it occurs in normal people.  Histamine is known to be a principal mediator of the triple response of Lewis, and to act via H 1  and H 2  receptors to produce vasodilatation and increased vascular permeability.  Neuropeptides contribute to the reaction. The reaction does not occur in chronically  denervated  skin, or in skin in which neuropeptides have been depleted by capsaicin. In  2–5% of the population, this response is exaggerated enough to be called dermographism. It occurs in seconds to minutes after the skin has been stroked. It is most easily diagnosed by using a calibrated instrument, the dermographometer, which has a spring-loaded stylus, the pressure of which can be adjusted to a predetermined setting. Stroking the skin at a tip pressure of less than 36 g/mm 2 induces a linear itching weal within 10 min.  The amount of vasodilatation can be measured by a Doppler flow meter

In delayed dermographism, a delay of several hours from the physical stimulus occurs before dermographism appears.  After normal fading of the triple response (or after an immediate dermographic response), a weal returns in the same site, but is usually tender and persists for up to 48 hours. It is closely related to pressure urticaria in which a delayed dermographic response is not unusual.

In red  dermographism, repeated rubbing is necessary to induce small punctate weals.

When accompanied by severe itching  dermographism is called symptomatic dermographism (a minority of those showing dermographism) . Symptomatic  dermographism  can  occur  at  any  age,  but  the  greatest incidence is in young adults. Patients complain of wealing  and marked itching at sites of trauma, friction with clothing or scratching  the  skin.  The  itching  is  usually  disproportionately  severe  compared with wealing and is often most severe at night. The eliciting stimulus determines the shape of the weals but they are often linear from scratching or stroking.

Dermographism is usually idiopathic. It may last for months or years, or be present intermittently. It may be associated with other forms of inducible urticaria. It may be present in chronic spontaneous urticariaIt may sometimes follow a drug or an infestationIt may occur in hypothyroidism and hyperthyroidism, infectious diseases, diabetes mellitus, and during onset of menopause. It may be a cause of localized or generalized pruritus. Localized symptomatic dermographism is a relatively common cause of urticaria to gloves in the absence of latex allergy.  Dermographism of clinically uninvolved skin is present in one third to one half of urticaria pigmentosa patients.   Dermographism is a feature of Sjögren–Larsson syndrome. In genital pruritus, it is useful to elicit dermographism of the inner thighs because such patients may be helped by oral antihistamine treatment. Dermographism may be associated with raised linear bands of infancy.   
      
Cholinergic dermographism is seen in some patients with cholinergic urticaria, whose dermographic response consists of an erythematous line studded with punctate weals characteristic of cholinergic weals.

Pallor (blanching) of the skin after stroking is called white dermographism. This reaction differs from the classic dermographism, in  that  it  typically  lacks  a  weal,  and  flaring is replaced by blanching to produce a white line. Typically seen in lesions of atopic eczema patients since the small blood vessels in these patients show a tendency to capillary vasoconstriction responses (different signalling but this does not mean that histamine is not increased). It becomes more evident with the chronicity of the disease but is absent following treatment.  It should be noted however that white dermographism occurs normally following light stroking of the skin but it is particularly pronounced in atopic eczema.

Black (or greenish) dermographism is discoloration of the skin after pressure from a metallic object. 

Other forms of true and false dermographism (not all forms of dermographism are urticaria) have been described.


Treatment of symptomatic immediate dermographism with low‐sedating H1  antihistamines is often effective, but some patients do not respond. The addition of an H2 antihistamine may be of benefit but it should be noted that dermograhism has been reported to be associated with the use of the H2 blocker famotidine. Sedating antihistamines such as hydroxyzine can be helpful.  Treatment may need to be continued regularly for at least several months; intermittent therapy is of less value. Omalizumab has been successfully used in patients with physical urticaria, including symptomatic dermographism. Resistant cases may find narrow band UVB phototherapy helpful.




_________________________________________________________________

*Ganong's Review of Medical Physiology: When a pointed object is drawn lightly over the skin, the stroke lines become pale (white reaction). The mechanical stimulus apparently initiates contraction of the precapillary sphincters, and blood drains out of the capillaries and small veins. The response appears in about 15 seconds. When the skin is stroked more firmly with a pointed instrument, instead of the white reaction there is reddening at the site that appears in about 10 seconds (red reaction). This is followed in a few minutes by local swelling and diffuse, mottled reddening around the injury. The initial redness is due to capillary dilatation, a direct response of the capillaries to pressure. The swelling (weal) is local oedema due to increased permeability of the capillaries and postcapillary venules, with consequent extravasation of fluid. The redness spreading out from the injury (flare) is due to arteriolar dilatation. This three-part response—the red reaction, weal, and flare—is called the triple response and is part of the normal reaction to injury. It is due to an axon reflex, a response in which impulses initiated in sensory nerves by the injury are relayed antidromically down other branches of the sensory nerve fibres. This is the one situation in the body in which there is substantial evidence for a physiologic effect due to antidromic conduction.

The page was last updated in August 2016

Tuesday, 2 August 2016

Berloque dermatitis



Berloque (a pendant) dermatitis is skin pigmentation due to phototoxic reaction to perfumes applied to the skin. Berloque dermatitis is considered a special form of phytophotodermatitis.

The reaction occurs commonly on the neck (hence the name berloque) and face. The acute inflammatory dermatitis due to berloque dermatitis might be unnoticed thus the patient presents with the streaky pigmentation. If the inflammatory phase is severe, bullae are formed. The distribution of the lesions is variable (and here it is on the upper limb) but their configuration is usually distinctive. Deepbrown  pigmentation  follows  the  pattern  formed  by  the  trickle  of  the droplets of perfume over the skin from their points of application.

Berloque dermatitis results from the potentiating of UVstimulated melanogenesis by 5methoxypsoralen (bergapten) in perfumes containing bergamot oil. If a fragrance containing this 5-methoxypsoralen (or another furocoumarin) is applied to the skin before exposure to the sun or tanning lights, berloque dermatitis may result. There are guidelines limiting the use of furocoumarins in some places. There is wide variation in susceptibility. This variation depends on the readiness with which the bergapten  is  absorbed,  the  quantity  applied,  and  the  intensity  and  duration  of  exposure  to  UV  light.  Susceptibility is increased by stripping the horny layer. Hot humid conditions favour absorption.  The pigmentation occurs in susceptible subjects who have been exposed to light after the application of perfume. Some regulations restrict the concentration of bergapten so that it is below the threshold required to cause dermatitis/pigmentation.


The reaction fades gradually over weeks to months. Sunscreens protect the skin from further sun exposure. If tinted, they can also disguise the lesions.


The child used to apply her mother’s perfume on the left upper limb. 


This page was last updated in August 2016

Sunday, 15 May 2016

Dermatology, aesthetic medicine and the private sector



"I do not like the cosmeticisation of dermatology - not what I did medicine to do," said Rona MacKie FRCP, in 2006 when asked about the dangers to the field of dermatology. In the following year, David Eedy FRCP wondered how the future generations would judge dermatologists’ preoccupation with the siren voices of cosmetic surgery. He added that dermatologists who heed the Delphic injunction to “know thyself” would be venerated.  He also added that dermatologists seriously run the risk of diluting their influence in medicine in general if they continue to follow the cosmetic route, which many other physicians quite rightly perceive is for financial gain rather than for the reasons why we all entered medicine in the first place. He believes that by not taking our careers in medicine seriously enough we will feel short-changed in the long term and less satisfied with the potential fullness of a career in dermatology.

The British National Health Service (NHS), the top model of a nationalised health system in the world, has recently been suffering a lot because higher costs have to be covered and now the private sector is apparently essential to maintain the NHS. It helps with the workload, brings new skills, and contributes to competition.  However, dermatology is a prime example of how government meddling is decimating the NHS through privatisation. Dermatology has been seen as an easy service for hard-pressed commissioners to shift ‘into the community’ with private providers, due to the widely held but mistaken view that skin diseases are minor ailments and can be easily identified and treated locally, reducing the burden on hospitals. The drive to shift treatment into the community leads to decommissioning of dermatology hospital services. There have been cases of private providers tendering for dermatology services without even having dermatologists or other appropriately trained staff in post!

In 2014, I referred to the risk Eedy referred to if the cosmetic route is being followed and I added that it certainly has taken place in many parts worldwide.


Few years ago, the British College of Aesthetic Medicine was established by general practitioners. Together with the British Association of Dermatologists, the British Association of Plastic Reconstructive and Aesthetic Surgeons, the British Association of Aesthetic Plastic Surgeons , and the British Association of Cosmetic Nurses, the newly established College will work to protect patients undergoing cosmetic interventions by improving and enforcing clinical standards and training, and by maintaining a register of practitioners. Whether the establishment of an independent Aesthetic Medicine College will stop dilution of dermatology influence in medicine or not remains to be seen.

This page was last updated in May 2016

Monday, 9 May 2016

Dermatology for the General Practitioner

Dermatology for the General Practitioner 


متبرع بالمحاضرة والرسوم الادارية الرمزية تحصل للنقابة

Date: Thursday 26 May 2016 at 3 pm. Duration: One hour

Venue: Egyptian Medical Syndicate

Registration: Egyptian Medical Syndicate 

Facebook Event Page






Monday, 8 February 2016

Fibroepithelial polyps of the anus (anal tags)



Fibroepithelial polyps of the anus are relatively common lesions, some of which are thought to arise from enlargement of anal papillae. Others are thought to arise from  fibrosed haemorrhoids

They are oedematous, flesh-coloured, sessile protrusions usually measuring 1–2 cm in length.  Underlying constipation might be present. Fibroepithelial polyps of the anus may be associated with local inflammation such as fissure, fistula and irritant or allergic contact dermatitis.  A variant associated with lichen sclerosus may also occur.

A fibroepithelial polyp of the anus has a myxoid and/or collagenous stroma covered by stratified squamous epithelium which may show some swollen cells with vacuolation near the surface. The stroma sometimes contains atypical cells showing fibroblastic and myofibroblastic differentiation. Hyalinized vascular changes may be present near the base of the polyps. There is an increase in CD34+ stromal cells.

Fibroepithelial polyps of the anus should not be mistaken for condylomas. They should also be distinguished from the much smaller transient infantile perianal pyramidal protrusion which occurs predominantly in young girls in the midline. Larger, fleshier, more oedematous skin tags should arouse the suspicion of Crohn’s disease. They can predate gastrointestinal disease by several years. Disturbance of the normal embryological development of the anus may rarely result in the appearance of one or more polypoid projections at the anus (anomalous anal papillae). These may be asymptomatic, but often become complicated by ulceration, faecal retention and constipation.

Fibroepithelial polyps of the anus  might be treated successfully by topical steroid applications however, removal is the standard treatment when required.




Before treatment


After treatment 




This page was last updated in March 2016













Main Works of Reference List (The first eight are my top favourites)

  • British National Formulary
  • British National Formulary for Children
  • Guidelines (BAD - BASHH - BHIVA - Uroweb)
  • Oxford Handbook of Genitourinary Medicine, HIV, and Sexual Health
  • Oxford Handbook of Medical Dermatology
  • Rook's Textbook of Dermatology
  • Simple Skin Surgery
  • Weedon's Skin Pathology
  • A Concise Atlas of Dermatopathology (P Mckee)
  • Ackerman's Resolving Quandaries in Dermatology, Pathology and Dermatopathology
  • Andrews' Diseases of the Skin
  • Andrology (Nieschlag E FRCP, Behre M and Nieschlag S)
  • Bailey and Love's Short Practice of Surgery
  • Davidson's Essentials of Medicine
  • Davidson's Principles and Practice of Medicine
  • Fitzpatrick's Colour Atlas and Synopsis of Clinical Dermatology (Klaus Wolff FRCP and Richard Allen Johnson)
  • Fitzpatrick’s Dermatology in General Medicine
  • Ganong's Review of Medical Physiology
  • Gray's Anatomy
  • Hamilton Bailey's Demonstrations of Physical Signs in Clinical Surgery
  • Hutchison's Clinical Methods
  • Lever's Histopathology of the Skin
  • Lever's Histopathology of the Skin (Atlas and Synopsis)
  • Macleod's Clinical Examination
  • Martindale: The Complete Drug Reference
  • Oxford Handbook of Clinical Examination and Practical Skills
  • Oxford Textbook of Medicine
  • Practical Dermatopathology (R Rapini)
  • Sexually Transmitted Diseases (Holmes K et al)
  • Statistics in Clinical Practice (D Coggon FRCP)
  • Stockley's Drug Interactions
  • Treatment of Skin Disease: Comprehensive Therapeutic Strategies
  • Yen & Jaffe's Reproductive Endocrinology